Here's a rundown of the 49ers injury report and what it all means for Sunday.
The 49ers will be without fullback Kyle Juszczyk, who was ruled out with a back injury. He has been a strong blocker in their run game, so this is certainly not an ideal loss. The 49ers send him out 30 percent of the time, give or take and do not have a backup fullback, so I am guessing that means an adjustment to the game plan.
The big names on defense are Reuben Foster and starting strong safety Eric Reid. Foster suffered a high ankle sprain in Week 1, and has been out since. He has been playing weak side linebacker, but with the surprising release of NaVorro Bowman, Foster will be taking over the middle linebacker role once healthy. He is listed as questionable after returning to practice in limited fashion. My guess is he plays this weekend, but I would not be surprised to see a rotation of sorts at MIKE and WILL. The 49ers have Foster and Ray-Ray Armstrong as their starters the rest of the year, but look for Brock Coyle to get some work, and potentially Elijah Lee and Mark Nzeocha.
Reid sprained his knee in Week 2, and is also questionable after three days of limited work. Jaquiski Tartt replaced him at strong safety. If Reid can play, Tartt would move into more of a dime backer role. Reid was playing extremely well as an in-the-box safety, and his return would give the safety depth chart a big boost.
Dekoda Watson and Adrian Colbert are the other two notable names. They play primarily special teams, although Watson has worked his way into some rotation at strong side linebacker. The 49ers special teams is among the best in the NFL, so getting those two back would add some useful depth.